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Deciphering the molecular mechanisms of mother-to-egg immune protection in the mealworm beetle Tenebrio molitor ArchiMer
Tetreau, Guillaume; Dhinaut, Julien; Galinier, Richard; Audant-lacour, Pascaline; Voisin, Sébastien N; Arafah, Karim; Chogne, Manon; Hilliou, Frédérique; Bordes, Anaïs; Sabarly, Camille; Chan, Philippe; Walet-balieu, Marie-laure; Vaudry, David; Duval, David; Bulet, Philippe; Coustau, Christine; Moret, Yannick; Gourbal, Benjamin.
In a number of species, individuals exposed to pathogens can mount an immune response and transmit this immunological experience to their offspring, thereby protecting them against persistent threats. Such vertical transfer of immunity, named trans-generational immune priming (TGIP), has been described in both vertebrates and invertebrates. Although increasingly studied during the last decade, the mechanisms underlying TGIP in invertebrates are still elusive, especially those protecting the earliest offspring life stage, i.e. the embryo developing in the egg. In the present study, we combined different proteomic and transcriptomic approaches to determine whether mothers transfer a “signal” (such as fragments of infecting bacteria), mRNA and/or...
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Ano: 2020 URL: https://archimer.ifremer.fr/doc/00655/76684/77815.pdf
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Trans-generational Immune Priming in Invertebrates: Current Knowledge and Future Prospects ArchiMer
Tetreau, Guillaume; Dhinaut, Julien; Gourbal, Benjamin; Moret, Yannick.
Trans-generational immune priming (TGIP) refers to the transfer of the parental immunological experience to its progeny. This may result in offspring protection from repeated encounters with pathogens that persist across generations. Although extensively studied in vertebrates for over a century, this phenomenon has only been identified 20 years ago in invertebrates. Since then, invertebrate TGIP has been the focus of an increasing interest, with half of studies published during the last few years. TGIP has now been tested in several invertebrate systems using various experimental approaches and measures to study it at both functional and evolutionary levels. However, drawing an overall picture of TGIP from available studies still appears to be a difficult...
Tipo: Text Palavras-chave: Trans-generational immune priming; Invertebrate immunity; Host-pathogens interaction; Ecology and evolution; Molecular mechanisms; Scenarios.
Ano: 2019 URL: https://archimer.ifremer.fr/doc/00512/62369/66642.pdf
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